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Advanced Renal Physiology and Pathophysiology

  • Course Number: GMS 6414
  • Credit Hours: 2 credit hours
  • Course Format: This online course is tailored for asynchronous distance learners.
  • Course Syllabus: View Full Course Details

Course Description

This is an advanced graduate class, also suitable for postdoctoral students, which will expose students to in-depth discussion and understanding of several aspects of kidney function, as follows: physiological control of glomerular filtration and glomerular function in renal disease; regulation of renal sodium excretion; morphology of renal transporters; renal mechanisms of acid base balance; and the renal physiologic responses to normal pregnancy. The teaching faculty are drawn from a wide range of disciplines and are all actively involved in research on their areas of expertise. The structure of this course involves 1) lectures by research faculty on areas of their expertise and 2) tutorial-style discussions on original articles which expand on the didactic lecture material.


This course requires a BA or BS and a strong science foundation with at least 5 full semester courses related to biology, chemistry and/or physics. In addition, Principles of Medical Physiology (GMS6400c) or equivalent are required.


Jaya Kolli, M.D., Lecturer of Physiology and Functional Genomics,, Tel: 352-273-8693.


This course is designed to be taken as part of the certificate in medical physiology program and should be preceded by GMS 6400C and GMS 6410.

Course Goals

The kidney is the primary regulator of all the body fluid compartments and controls both volume and composition. This course explores: 1) the mechanisms by which filtration of fluid occurs at the glomerulus; 2) some current ideas on the causes of progression of chronic kidney disease; 3) molecular aspects of structural and functional regulation of renal sodium excretion; 4) advances in the molecular understanding of the kidney and acid base balance; and 5) the complex renal adaptations that occur in renal hemodynamics and sensing and control of sodium balance during normal pregnancy.